She also entered the doubles with Ľudmila Cervanová. She progressed through three qualifying rounds and beat Shinobu Asagoe in the first round before losing to Sarah Pitkowski-Malcor in the second round.They beat Květa Peschke and Barbara Rittner in the round of sixteen and lost to Nathalie Dechy and Henrieta Nagyová in the quarterfinal. Hantuchová's next three tournaments were the Miami Masters, where she received a wildcard and lost in the first round to Elena Dementieva 7–5, 3–6, 2–6; the MPS Group Championships, where she lost in the first qualifying round to Pavlina Nola, and the Belgian Open, where she lost in the first round to Kim Clijsters.
Hantuchová reached her second semifinal of the year at the DFS Classic in Birmingham in June.Hantuchová became the 37th woman in the Open Era to reach 500 career wins when she beat Laura Robson in the second round of the Aegon Classic in June 2013.Hantuchová is also an accomplished doubles player, achieving a career-high doubles ranking of world No. In 2005, she completed the career Grand Slam in mixed doubles, becoming only the fifth female tennis player to do so.They were due to face Petra Mandula and Patricia Wartusch in the final, but they withdrew and Hantuchová and Habšudová won in a walkover. Her final tournament of the year was the Advanta Championships of Philadelphia.In the first round, she beat Alexandra Stevenson, who retired injured after the end of the first set. Hantuchová began 2001 at the Adidas International in Sydney, where she lost in the first qualifying round.